CHRNA10 Antikörper (AA 394-443)

Produktnummer ABIN1535099

Der Kaninchen Polyklonal anti-CHRNA10 Antikörper (ABIN1535099) detektiert spezifisch CHRNA10 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für CHRNA10 Antikörper (AA 394-443) (ABIN1535099)

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRNA10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CHRNA10 Antikörper

Bindungsspezifität: AA 394-443

Verwendungszweck: AChRα10 Antibody

Spezifität: AChRα10 Polyclonal Antibody detects endogenous levels of AChRα10 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CHRNA10. AA range:394-443

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CHRNA10

Target: CHRNA10 (Cholinergic Receptor, Nicotinic, alpha 10 (CHRNA10))

Andere Bezeichnung: CHRNA10

Hintergrund:

Synonyms: CHRNA10, NACHRA10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10

Background: function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.,miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.,tissue specificity:Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.,

Gene Name: CHRNA10

Protein Name: Neuronal acetylcholine receptor subunit alpha-10

Molekulargewicht: 49 kDa

Gen-ID: 57053

OMIM: 606372

UniProt: Q9GZZ6

Pathways: Sensory Perception of Sound, Synaptic Membrane