GAD65+GAD67 (AA 545-594) Antikörper

Produktnummer ABIN1533282

Der Kaninchen Polyklonal anti-GAD65+GAD67 Antikörper wird verwendet zum Nachweis von GAD65+GAD67 in Proben von Human und Maus. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für GAD65+GAD67 (AA 545-594) Antikörper (ABIN1533282)

Target: GAD65+GAD67

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails

Bindungsspezifität: AA 545-594

Verwendungszweck: GAD-65/67 Antibody

Spezifität: GAD-65/67 Polyclonal Antibody detects endogenous levels of GAD-65/67 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human GAD1/2. AA range:545-594

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Antigendetails

Target: GAD65+GAD67

Andere Bezeichnung: GAD1/2

Hintergrund:

Synonyms: GAD1, GAD, GAD67, Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD2, GAD65, Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65

Background: glutamate decarboxylase 1(GAD1) Homo sapiens This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008],

Gene Name: GAD1/GAD2

Protein Name: Glutamate decarboxylase 1/2

Molekulargewicht: 66 kDa

Gen-ID: 2571, 2572

OMIM: 605363

UniProt: Q99259