Claudin 11 Antikörper (AA 158-207)

Produktnummer ABIN1533234

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Claudin 11 Antikörper wird verwendet zum Nachweis von Claudin 11 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für Claudin 11 Antikörper (AA 158-207) (ABIN1533234)

Target: Claudin 11 (CLDN11)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Claudin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Claudin 11 Antikörper

Bindungsspezifität: AA 158-207

Verwendungszweck: Claudin-11 Antibody

Spezifität: Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-Claudin 11 Antikörper (ABIN1533234)

Mogk, Meiwes, Shtopel, Schraermeyer, Lazarus, Kubata, Wolburg, Duszenko: "Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS." in: PLoS ONE, Vol. 9, Issue 3, pp. e91372, (2014) (PubMed).

Details zu Claudin 11

Target: Claudin 11 (CLDN11)

Andere Bezeichnung: Claudin 11

Hintergrund:

Synonyms: CLDN11, OSP, OTM, Claudin-11, Oligodendrocyte-specific protein

Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso

Gene Name: CLDN11

Protein Name: Claudin-11

Molekulargewicht: 21 kDa

Gen-ID: 5010

OMIM: 601326

UniProt: O75508

Pathways: Hepatitis C