LRP1 Antikörper (AA 4486-4535)

Produktnummer ABIN1533132

Der Kaninchen Polyklonal anti-LRP1 Antikörper wird verwendet zum Nachweis von LRP1 in Proben von Human und Maus. Er wurde validiert für WB, IHC, ELISA und IF.

Kurzübersicht für LRP1 Antikörper (AA 4486-4535) (ABIN1533132)

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-LRP1 Antikörper

Bindungsspezifität: AA 4486-4535

Verwendungszweck: LRP1 Antibody

Spezifität: LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CD91. AA range:4486-4535

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu LRP1

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Andere Bezeichnung: CD91

Hintergrund:

Synonyms: LRP1; A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91

Background: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015],

Gene Name: LRP1

Protein Name: Prolow-density lipoprotein receptor-related protein 1

Molekulargewicht: 504 kDa

Gen-ID: 4035

OMIM: 107770

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling