LRP1 Antikörper (AA 20-270)

Produktnummer ABIN3021969

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-LRP1 Antikörper wird verwendet zum Nachweis von LRP1 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für LRP1 Antikörper (AA 20-270) (ABIN3021969)

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-LRP1 Antikörper

Bindungsspezifität: AA 20-270

Sequenz: AIDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE APEICPQSKA QRCQPNEHNC LGTELCVPMS RLCNGVQDCM DGSDEGPHCR ELQGNCSRLG CQHHCVPTLD GPTCYCNSSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFICGCVEGY LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN ETVCWVHVGD SAAQTQLKCA RMPGLKGFVD E

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human LRP1 (NP_002323.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-LRP1 Antikörper (ABIN3021969)

Kong, Han, Cui, Zhou, Jiang, Zhang, Wang, Wang, Zhang: "MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice." in: Endocrine, Vol. 53, Issue 2, pp. 595-606, (2017) (PubMed).

Details zu LRP1

Target: LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))

Andere Bezeichnung: LRP1

Hintergrund: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.,LRP1,A2MR,APOER,APR,CD91,IGFBP3R,KPA,LRP,LRP1A,TGFBR5,Epigenetics & Nuclear Signaling,RNA Binding,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Microtubules,Wnt/β-Catenin Signaling Pathway,ESC Pluripotency and Differentiation,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Immunology & Inflammation,CD markers,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,Blood,Serum Proteins,Lipids,LRP1

Molekulargewicht: 31 kDa/504 kDa

Gen-ID: 4035

UniProt: Q07954

Pathways: Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling