PAK4 Antikörper (AA 441-490)

Produktnummer ABIN1532472

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PAK4 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für PAK4 Antikörper (AA 441-490) (ABIN1532472)

Target: PAK4 (P21-Activated Kinase 4 (PAK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PAK4 Antikörper

Bindungsspezifität: AA 441-490

Verwendungszweck: PAK4/5/6 Antibody

Spezifität: PAK4/5/6 Polyclonal Antibody detects endogenous levels of PAK4/5/6 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human PAK4/5/6. AA range:441-490

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu PAK4

Target: PAK4 (P21-Activated Kinase 4 (PAK4))

Andere Bezeichnung: PAK4/5/6

Hintergrund:

Synonyms: PAK4, KIAA1142, Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4

Background: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Gene Name: PAK4 PAK5 PAK6

Protein Name: Serine/threonine-protein kinase PAK 4

Molekulargewicht: 64 kDa

Gen-ID: 10298

OMIM: 605451

UniProt: O96013

Pathways: RTK Signalweg