FLT3 Antikörper (pTyr969)

Produktnummer ABIN1532045

Der Kaninchen Polyklonal anti-FLT3 Antikörper (ABIN1532045) detektiert spezifisch FLT3 in WB, ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für FLT3 Antikörper (pTyr969) (ABIN1532045)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-FLT3 Antikörper

Bindungsspezifität: AA 935-984, pTyr969

Verwendungszweck: Flt-3 (phospho Tyr969) Antibody

Spezifität: Phospho-Flt-3 (Y969) Polyclonal Antibody detects endogenous levels of Flt-3 protein only when phosphorylated at Y969.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human FLT3 around the phosphorylation site of Tyr969. AA range:935-984

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Andere Bezeichnung: FLT3

Hintergrund:

Synonyms: FLT3, CD135, FLK2, STK1, Receptor-type tyrosine-protein kinase FLT3, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD antigen CD135

Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],

Gene Name: FLT3

Protein Name: Receptor-type tyrosine-protein kinase FLT3

Molekulargewicht: 112 kDa

Gen-ID: 2322

OMIM: 136351

UniProt: P36888

Pathways: RTK Signalweg