Nibrin Antikörper (pSer278)

Produktnummer ABIN1531747

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Nibrin in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Nibrin Antikörper (pSer278) (ABIN1531747)

Target: Nibrin (NBN)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nibrin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-Nibrin Antikörper

Bindungsspezifität: AA 251-300, pSer278

Verwendungszweck: Nibrin (phospho Ser278) Antibody

Spezifität: Phospho-Nibrin (S278) Polyclonal Antibody detects endogenous levels of Nibrin protein only when phosphorylated at S278.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Nibrin around the phosphorylation site of Ser278. AA range:251-300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Nibrin

Target: Nibrin (NBN)

Andere Bezeichnung: Nibrin

Hintergrund:

Synonyms: NBN, NBS, NBS1, P95, Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1

Background: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008],

Gene Name: NBN

Protein Name: Nibrin

Molekulargewicht: 84 kDa

Gen-ID: 4683

OMIM: 114480

UniProt: O60934

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response