NCF1 Antikörper (pSer370)

Produktnummer ABIN1531722

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-NCF1 Antikörper (ABIN1531722) detektiert spezifisch NCF1 in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für NCF1 Antikörper (pSer370) (ABIN1531722)

Target: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-NCF1 Antikörper

Bindungsspezifität: AA 341-390, pSer370

Verwendungszweck: p47-phox (phospho Ser370) Antibody

Spezifität: Phospho-p47-phox (S370) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S370.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser370. AA range:341-390

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Referenzen für anti-NCF1 Antikörper (ABIN1531722)

Lee, Lee, Park, Jang, Kim, Kim: "Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia." in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, (2016) (PubMed).

Lee, Ko, Jeong, Park, Kim: "β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia." in: Journal of neuroinflammation, Vol. 12, pp. 133, (2015) (PubMed).

Details zu NCF1

Target: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Andere Bezeichnung: p47 phox

Hintergrund:

Synonyms: NCF1, NOXO2, SH3PXD1A, Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3

Background: The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008],

Gene Name: NCF1

Protein Name: Neutrophil cytosol factor 1

Molekulargewicht: 44 kDa

Gen-ID: 653361

OMIM: 233700

UniProt: P14598

Pathways: PI3K-Akt Signalweg