WASF1 Antikörper (pTyr125)

Produktnummer ABIN1531413

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch WASF1 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für WASF1 Antikörper (pTyr125) (ABIN1531413)

Target: WASF1 (WAS Protein Family, Member 1 (WASF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WASF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-WASF1 Antikörper

Bindungsspezifität: AA 91-140, pTyr125

Verwendungszweck: WAVE1 (phospho Tyr125) Antibody

Spezifität: Phospho-WAVE1 (Y125) Polyclonal Antibody detects endogenous levels of WAVE1 protein only when phosphorylated at Y125.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human WAVE1 around the phosphorylation site of Tyr125. AA range:91-140

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu WASF1

Target: WASF1 (WAS Protein Family, Member 1 (WASF1))

Andere Bezeichnung: WAVE1

Hintergrund:

Synonyms: WASF1, KIAA0269, SCAR1, WAVE1, Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1

Background: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Gene Name: WASF1

Protein Name: Wiskott-Aldrich syndrome protein family member 1

Molekulargewicht: 61 kDa

Gen-ID: 8936

OMIM: 605035

UniProt: Q92558

Pathways: RTK Signalweg, Regulation of Actin Filament Polymerization