Cathepsin B Antikörper (AA 168-217)

Produktnummer ABIN1453029

Der Kaninchen Polyklonal anti-Cathepsin B Antikörper (ABIN1453029) detektiert spezifisch Cathepsin B in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Cathepsin B Antikörper (AA 168-217) (ABIN1453029)

Target: Cathepsin B (CTSB)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-Cathepsin B Antikörper

Bindungsspezifität: AA 168-217

Verwendungszweck: Cathepsin B Antibody

Spezifität: Cathepsin B Polyclonal Antibody detects endogenous levels of Cathepsin B protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human Cathepsin B. AA range:168-217

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Cathepsin B

Target: Cathepsin B (CTSB)

Andere Bezeichnung: Cathepsin B

Hintergrund:

Synonyms: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1

Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.

Gene Name: CTSB

Protein Name: Cathepsin B

Molekulargewicht: 37 kDa

Gen-ID: 1508

OMIM: 116810

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades