C1R Antikörper (Cleaved-Arg463)

Produktnummer ABIN1452252

Der Kaninchen Polyklonal anti-C1R Antikörper (ABIN1452252) detektiert spezifisch C1R in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für C1R Antikörper (Cleaved-Arg463) (ABIN1452252)

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-C1R Antikörper

Bindungsspezifität: AA 414-463, Cleaved-Arg463

Verwendungszweck: Cleaved-C1r HC (R463) Antibody

Spezifität: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human C1R. AA range:414-463

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu C1R

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Andere Bezeichnung: C1R

Hintergrund:

Synonyms: C1R, Complement C1r subcomponent, Complement component 1 subcomponent r

Background: catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).,function:C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.,polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.,

Gene Name: C1R

Protein Name: Complement C1r subcomponent

Molekulargewicht: 80 kDa

Gen-ID: 715

OMIM: 216950

UniProt: P00736

Pathways: Komplementsystem