RNF111 Antikörper (AA 901-950)

Produktnummer ABIN1451235

Der Kaninchen Polyklonal anti-RNF111 Antikörper (ABIN1451235) detektiert spezifisch RNF111 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für RNF111 Antikörper (AA 901-950) (ABIN1451235)

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF111 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RNF111 Antikörper

Bindungsspezifität: AA 901-950

Verwendungszweck: Arkadia Antibody

Spezifität: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Andere Bezeichnung: RNF111

Hintergrund:

Synonyms: RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111

Background: ring finger protein 111(RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Gene Name: RNF111

Protein Name: E3 ubiquitin-protein ligase Arkadia

Molekulargewicht: 108 kDa

Gen-ID: 54778

OMIM: 605840

UniProt: Q6ZNA4