RNF111 Antikörper (AA 870-950)

Produktnummer ABIN7223318

Der Kaninchen Polyklonal anti-RNF111 Antikörper wird verwendet zum Nachweis von RNF111 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für RNF111 Antikörper (AA 870-950) (ABIN7223318)

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF111 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RNF111 Antikörper

Bindungsspezifität: AA 870-950

Verwendungszweck: Rabbit Anti-Arkadia Polyclonal Antibody

Spezifität: Arkadia Polyclonal Antibody detects endogenous levels of Arkadia protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Arkadia at AA range: 870-950

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:40000,Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Andere Bezeichnung: Arkadia

Hintergrund: RNF111, E3 ubiquitin-protein ligase Arkadia, RING finger protein 111The protein encoded by RNF111 (ring finger protein 111) is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF)-beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of RNF111 results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 110kD

Gen-ID: 54778

UniProt: Q6ZNA4