Complement Factor I Antikörper (AA 441-490)

Produktnummer ABIN1451187

Der Kaninchen Polyklonal anti-Complement Factor I Antikörper (ABIN1451187) detektiert spezifisch Complement Factor I in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Complement Factor I Antikörper (AA 441-490) (ABIN1451187)

Target: Complement Factor I (CFI)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement Factor I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Complement Factor I Antikörper

Bindungsspezifität: AA 441-490

Verwendungszweck: Factor I Antibody

Spezifität: Factor I Polyclonal Antibody detects endogenous levels of Factor I protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from human CFI. AA range:441-490

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Complement Factor I

Target: Complement Factor I (CFI)

Andere Bezeichnung: CFI

Hintergrund:

Synonyms: CFI, IF, Complement factor I, C3B/C4B inactivator

Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by Ref

Gene Name: CFI

Protein Name: Complement factor I

Molekulargewicht: 65 kDa

Gen-ID: 3426

OMIM: 217030

UniProt: P05156

Pathways: Komplementsystem