PIWIL2 Antikörper (Middle Region)

Produktnummer ABIN1450162

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch PIWIL2 in IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PIWIL2 Antikörper (Middle Region) (ABIN1450162)

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIWIL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PIWIL2 Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: A 14 amino acid synthetic peptide near the center of Human PIWI-L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PIWIL2

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Andere Bezeichnung: PIWIL2

Hintergrund: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.Synonyms: CT80, Cancer/testis antigen 80, HILI, Hiwi-like, Mili, Miwi-like, PIWIL1L, Piwi-like protein 2

Gen-ID: 55124

NCBI Accession: NP_00129193

Pathways: Stem Cell Maintenance