PIWIL2 Antikörper (Middle Region)

Produktnummer ABIN1450162

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PIWIL2 in IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PIWIL2 Antikörper (Middle Region) (ABIN1450162)

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIWIL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-PIWIL2 Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: A 14 amino acid synthetic peptide near the center of Human PIWI-L2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PIWIL2

Target: PIWIL2 (Piwi-Like 2 (PIWIL2))

Andere Bezeichnung: PIWIL2

Hintergrund: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.Synonyms: CT80, Cancer/testis antigen 80, HILI, Hiwi-like, Mili, Miwi-like, PIWIL1L, Piwi-like protein 2

Gen-ID: 55124

NCBI Accession: NP_00129193

Pathways: Stem Cell Maintenance