HHATL Antikörper (N-Term)

Produktnummer ABIN1450142

Der Kaninchen Polyklonal anti-HHATL Antikörper wird verwendet zum Nachweis von HHATL in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p), IF und EIA.

Kurzübersicht für HHATL Antikörper (N-Term) (ABIN1450142)

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HHATL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-HHATL Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the amino terminus of Human HHATL

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HHATL

Target: HHATL (Hedgehog Acyltransferase-Like (HHATL))

Andere Bezeichnung: GUP1 / HHATL

Hintergrund: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development .Synonyms: C3orf3, Glycerol uptake/transporter homolog, Hedgehog acyltransferase-like protein, KIAA1173, Protein-cysteine N-palmitoyltransferase HHAT-like protein

Gen-ID: 57467

NCBI Accession: NP_065758

Pathways: Hedgehog Signalweg