Nkx2-2 Antikörper (Middle Region)

Produktnummer ABIN1450127

Der Kaninchen Polyklonal Anti-Nkx2-2-Antikörper wurde für IF, IHC (p), WB und EIA validiert. Er ist geeignet, Nkx2-2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Nkx2-2 Antikörper (Middle Region) (ABIN1450127)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nkx2-2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Nkx2-2 Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid synthetic peptide near the center of Human NKX2-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Andere Bezeichnung: NKX2-2

Hintergrund: NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature alpha-, beta- and PP cells, and in NKX2-2-null mice embryos, all beta-cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.Synonyms: Homeobox protein Nkx-2.2, NK2 transcription factor related, NKX2.2, NKX2B, locus 2

Gen-ID: 4821

NCBI Accession: NP_002500

Pathways: Dopaminergic Neurogenesis