C9ORF116 Antikörper (N-Term)

Produktnummer ABIN1450123

Produktdetails anti-C9ORF116 Antikörper

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C9ORF116 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid synthetic peptide near the amino terminus of Human PIERCE1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu C9ORF116

Target: C9ORF116 (Chromosome 9 Open Reading Frame 116 (C9ORF116))

Andere Bezeichnung: C9orf116 (C9ORF116 Produkte)

Synonyme: PIERCE1 antikoerper, RbEST47 antikoerper, Rbest47 antikoerper, chromosome 9 open reading frame 116 antikoerper, RIKEN cDNA 1700007K13 gene antikoerper, chromosome ssa24 open reading frame, human C9orf116 antikoerper, chromosome 11 open reading frame, human C9orf116 antikoerper, C9orf116 antikoerper, 1700007K13Rik antikoerper, cssa24h9orf116 antikoerper, C11H9orf116 antikoerper

Hintergrund: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation (1,2). PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer (3-4). PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies (1-3).Synonyms: Pierce1, p53-induced expression in RB-null cells protein 1

Gen-ID: 138162

NCBI Accession: NP_001041730