DPAGT1 Antikörper (N-Term)

Produktnummer ABIN1450055

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-DPAGT1 Antikörper wird verwendet zum Nachweis von DPAGT1 in Proben von Human und Maus. Er wurde validiert für WB, IHC (p), IF und EIA.

Kurzübersicht für DPAGT1 Antikörper (N-Term) (ABIN1450055)

Target: DPAGT1 (Dolichyl-Phosphate (UDP-N-Acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P Transferase) (DPAGT1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPAGT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-DPAGT1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the amino terminus of Human DPAGT1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-DPAGT1 Antikörper (ABIN1450055)

Niewiadomska, Janik, Perlińska-Lenart, Piłsyk, Palamarczyk, Kruszewska: "The role of Alg13 N-acetylglucosaminyl transferase in the expression of pathogenic features of Candida albicans." in: Biochimica et biophysica acta. General subjects, Vol. 1861, Issue 4, pp. 789-801, (2017) (PubMed).

Details zu DPAGT1

Target: DPAGT1 (Dolichyl-Phosphate (UDP-N-Acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P Transferase) (DPAGT1))

Andere Bezeichnung: DPAGT1

Hintergrund: The UDP-N-acetylglucosamine-dolichyl-phosphate N-acetyl-glucosaminephosphotransferase (DPAGT1) is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. Mutations in this integral endoplasmic reticulum (ER) membrane protein enzyme belongs to the glycosyltransferase family 4 results in the congenital disorder of glycosylation type Ij with symptoms such as severe hypotonia, medically intractable seizures, mental retardation, microcephaly, and exotropia. Recent experiments have shown that DPAGT1 is a target of the Wnt/beta-catenin signaling pathway, with Wnt3a inducing higher DPAGT1 mRNA expression.Synonyms: DPAGT2, G1PT, GPT, GlcNAc-1-P transferase, N-acetylglucosamine-1-phosphate transferase, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase

Gen-ID: 1798

NCBI Accession: NP_001373