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PHLPP2 Antikörper (C-Term)

PHLPP2 Reaktivität: Human WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1449986
  • Target Alle PHLPP2 Antikörper anzeigen
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Bindungsspezifität
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 16
    • 5
    • 2
    • 1
    • 1
    Human
    Wirt
    • 15
    • 1
    Kaninchen
    Klonalität
    • 16
    Polyklonal
    Konjugat
    • 16
    Dieser PHLPP2 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2.
    Isotyp
    IgG
    Top Product
    Discover our top product PHLPP2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Andere Bezeichnung
    PHLPP2 (PHLPP2 Produkte)
    Synonyme
    PHLPPL antikoerper, phlppl antikoerper, AI481772 antikoerper, C130044A18Rik antikoerper, Phlppl antikoerper, RGD1562857 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antikoerper, PHLPP2 antikoerper, phlpp2.S antikoerper, phlpp2 antikoerper, Phlpp2 antikoerper
    Hintergrund
    PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation .Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL
    Molekulargewicht
    156 kDa
    Gen-ID
    23035
    NCBI Accession
    NP_055835
    Pathways
    PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung
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