SCIMP Antikörper

Produktnummer ABIN1449307

Dieser Maus Monoklonal Antikörper detektiert spezifisch SCIMP in IP, WB, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SCIMP Antikörper (ABIN1449307)

Target: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCIMP Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: NVL-07

Produktdetails anti-SCIMP Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure by SDS-PAGE

Immunogen: Recombinant intracellular part of human SCIMP

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), approx. pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SCIMP

Target: SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))

Andere Bezeichnung: SCIMP

Hintergrund: SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.Synonyms: SLP adaptor and Csk interacting membrane protein

Gen-ID: 388325

NCBI Accession: NP_996986

UniProt: Q6UWF3