NUMA1 Antikörper

Produktnummer ABIN1449239

Der Maus Monoklonal Anti-NUMA1-Antikörper wurde für WB, IF und IP validiert. Er ist geeignet, NUMA1 in Proben von Human zu detektieren.

Kurzübersicht für NUMA1 Antikörper (ABIN1449239)

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: C02142

Produktdetails anti-NUMA1 Antikörper

Spezifität: This antibody reacts with human NuMA.

Aufreinigung: Protein A agarose

Immunogen: Protein fraction extracted from the mitotic chromosome

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: NuMA

Hintergrund: NuMA (Nuclear Mitotic Apparatus Protein) is involved in maintenance of nuclear structure and in the assembly of the mitotic spindle. During interphase, NuMA is present throughout the nucleus, and during mitosis, it localizes to the spindle. It associates with microtubule motors during mitosis, and plays an essential role in anchoring microtubule ends to the spindle poles. NuMA is an autoantigen, and some individuals with connective tissue disease or other autoimmune disorders have antibodies directed against the NuMA protein. Recent data suggests NuMA (240 kDa) is cleaved to a 180-200 kDa form during apoptosis.Synonyms: NUMA1, Nuclear mitotic apparatus protein 1, SP-H antigen

Molekulargewicht: 240 kDa

Gen-ID: 4926

NCBI Accession: NP_006176

UniProt: Q14980

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase