KPNB1 Antikörper

Produktnummer ABIN1449199

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch KPNB1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für KPNB1 Antikörper (ABIN1449199)

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reaktivität: Human, Maus, Ratte

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser KPNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1D7

Produktdetails anti-KPNB1 Antikörper

Spezifität: This antibody detects Importin β.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G agarose

Immunogen: Recombinant full-length mouse importin beta

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu KPNB1

Target: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Andere Bezeichnung: NTF97

Hintergrund: Importin ß (karyopherin ß/PTAC97) forms a complex with importin a that is required for classical import of proteins across the nuclear envelope through the nuclear pore complex. Importin a acts as a bridge between the nuclear localization sequence (NLS) and importin ß, while importin ß is the site of initial docking to the pore and is responsible for transport of the target protein into the nucleus. Inside the nucleus, Ran-GTP binds to importin ß, resulting in dissociation of the ternary complex, and importin a and ß are independently recycled back into the cytoplasm. Recently some NLS-containing proteins have been shown to bind directly to importin ß and enter the nucleus in an importin a independent manner.Synonyms: Importin subunit beta-1, Importin-90, KPNB1, Nuclear factor P97

Molekulargewicht: 96 kDa

Gen-ID: 3837

NCBI Accession: NP_002256

UniProt: Q14974

Pathways: Protein targeting to Nucleus