CYBA Antikörper

Produktnummer ABIN1449193

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CYBA in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CYBA Antikörper (ABIN1449193)

Target: CYBA (Cytochrome B-245, alpha Polypeptide (CYBA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYBA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 7D5

Produktdetails anti-CYBA Antikörper

Spezifität: This antibody reacts with an extracellular epitope of gp91phox. The antibody recognizes the epitope in the native conformation or after treatment with guanidine or urea, but SDS treatment will abolish antibody binding.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A agarose

Immunogen: Human cytochrome b rich fraction

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store (in aliqouts) at -20 °C.

Details zu CYBA

Target: CYBA (Cytochrome B-245, alpha Polypeptide (CYBA))

Andere Bezeichnung: Cytochrome B-245 Light Chain

Hintergrund: The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2 -), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome B558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2 -. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections.Synonyms: CYBA, Cytochrome b(558) alpha chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, p22 phagocyte B-cytochrome, p22-phox

Gen-ID: 1535

NCBI Accession: NP_000092

UniProt: P13498

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Carbohydrate Homeostasis