KIAA0319 Antikörper (PE)

Produktnummer ABIN1428560

Der Kaninchen Polyklonal Anti-KIAA0319-Antikörper wurde für WB validiert. Er ist geeignet, KIAA0319 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für KIAA0319 Antikörper (PE) (ABIN1428560)

Target: KIAA0319

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIAA0319 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB)

Produktdetails anti-KIAA0319 Antikörper (PE)

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DYX2/KIAA0319

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:20-100)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KIAA0319

Target: KIAA0319

Andere Bezeichnung: Dyx2/Kiaa0319

Hintergrund:

Synonyms: DLX 2, DLX2, DYLX 2, DYLX2, Dyslexia susceptibility 2, Dyslexia-associated protein KIAA0319 DYX 2, DYX2, K0319_HUMAN, Kiaa0319, MGC176717.

Background: DYX2 is a 1072 amino acid single-pass transmembrane protein that contains one MANSC domain and two PKD (Polycystic Kidney Disease) domains, which are usually found in the extracellular regions of proteins and are involved in protein-protein interactions. In DYX2, it is likely that its PKD domains mediate the interaction between neurons and glial fibers during neuronal migration. When overexpressed, this plasma membrane protein colocalizes with EEA1 (early endosome antigen 1) in large intracellular vesicles, suggesting that it is endocytosed and recycled. DYX2 is highly expressed in brain cortex, cerebellum, amygdala, putamen and hippocampus. Defects in the gene encoding DYX2 may be the cause of dyslexia type 2, a relatively common disorder that is characterized by reading performance impairment in the absence of sensory or neurologic disability. There are three isoforms of DYX2 that are produced as a result of alternative splicing events