Unc5c Antikörper (PE)

Produktnummer ABIN1426750

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Unc5c in FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Unc5c Antikörper (PE) (ABIN1426750)

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Unc5c Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Unc5c Antikörper (PE)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UNC5H3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:20-100)

Kommentare:

Exitation/Emission: 480,565nm/578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4°C

Haltbarkeit: 12 months

Details zu Unc5c

Target: Unc5c (Unc-5 Homolog C (C. Elegans) (Unc5c))

Andere Bezeichnung: Unc5h3/Unc5c

Hintergrund:

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H3, also known as UNC5C, plays an important role in the development of spinal accessory motor neurons. It is also involved in mediating the repulsive action for netrin-1 and it serves as a stop signal for migratory cells.

Subcellular location: Extracellular

Synonyms: Alternative nameshomolog of C. elegans transmembrane receptor Unc5, Netrin receptor UNC5C, Protein unc 5 homolog C, Unc 5 homolog 3, Unc 5 homolog C, Unc5 C.elegans homolog c, UNC5H3, UNC5C_HUMAN.