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FEZ1 Antikörper (Cy3)

Der Kaninchen Polyklonal Anti-FEZ1-Antikörper wurde für WB und IF (p) validiert. Er ist geeignet, FEZ1 in Proben von Human, Ratte und Maus zu detektieren.
Produktnummer ABIN1422155

Kurzübersicht für FEZ1 Antikörper (Cy3) (ABIN1422155)

Target

Alle FEZ1 Antikörper anzeigen
FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

Reaktivität

Human, Ratte, Maus

Wirt

  • 25
  • 2
  • 1
Kaninchen

Klonalität

  • 28
Polyklonal

Konjugat

  • 11
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FEZ1 Antikörper ist konjugiert mit Cy3

Applikation

  • 23
  • 12
  • 6
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Kreuzreaktivität

    Human, Maus, Ratte

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human FEZ1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))

    Andere Bezeichnung

    FEZ1

    Hintergrund

    Synonyms: Fasciculation and elongation protein zeta 1, Fasciculation and elongation protein zeta-1, Fez 1, Fez, Fez-like zinc finger protein, FEZ1, FEZ1_HUMAN, Fezl, Forebrain embryonic zinc-finger like protein, Zpf312, Zygin 1, Zygin I, Zygin-1, Zygin1, ZyginI.

    Background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

    Gen-ID

    9638
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