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FEZ1 Antikörper

FEZ1 Reaktivität: Human, Ratte, Maus WB, IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387129
  • Target Alle FEZ1 Antikörper anzeigen
    FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
    Reaktivität
    Human, Ratte, Maus
    Wirt
    • 25
    • 2
    • 1
    Kaninchen
    Klonalität
    • 28
    Polyklonal
    Konjugat
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FEZ1 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 12
    • 6
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FEZ1
    Isotyp
    IgG
    Top Product
    Discover our top product FEZ1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    FEZ1 (Fasciculation and Elongation Protein zeta 1 (Zygin I) (FEZ1))
    Andere Bezeichnung
    FEZ1 (FEZ1 Produkte)
    Synonyme
    UNC-76 antikoerper, UNC76 antikoerper, wu:fj14c12 antikoerper, zgc:73258 antikoerper, fez1 antikoerper, xfez1 antikoerper, fasciculation and elongation protein zeta 1 antikoerper, fasciculation and elongation protein zeta 1 (zygin I) antikoerper, fasciculation and elongation protein zeta 1 L homeolog antikoerper, FEZ1 antikoerper, Fez1 antikoerper, fez1 antikoerper, fez1.L antikoerper
    Hintergrund

    Synonyms: Fasciculation and elongation protein zeta 1, Fasciculation and elongation protein zeta-1, Fez 1, Fez, Fez-like zinc finger protein, FEZ1, FEZ1_HUMAN, Fezl, Forebrain embryonic zinc-finger like protein, Zpf312, Zygin 1, Zygin I, Zygin-1, Zygin1, ZyginI.

    Background: Frequent loss of heterozygosity (LOH) at human chromosome 8p22-p21 is associated with various tumors including prostate and breast cancer. The 8p22-p21 region contains the FEZ1 gene, which is altered in tumors of the esophagus, prostate and breast. The FEZ1 protein (also known as leucine zipper putative tumor suppressor or LZTS1) contains a DNA-binding leucine zipper motif. FEZ1 is expressed in normal breast and prostate, but alterations in FEZ1 expression result in abnormal cell growth. The absence of FEZ1 expression is characteristic of breast and prostate cancer cell lines as well as primary breast and pro-state tumors. This absence of FEZ1 may be due to several factors, including mutations in the FEZ1 gene or hypermethylation of the CpG island flanking the FEZ1 promoter region. FEZ1 acts as a negative regulator of cell growth. During cell-cycle progression, FEZ1 localizes to microtubule components and is hyperphosphorylated by cAMP-dependent kinase.

    Gen-ID
    9638
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