ZNRF1 Antikörper (Cy5.5)

Produktnummer ABIN1418929

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ZNRF1 in IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ZNRF1 Antikörper (Cy5.5) (ABIN1418929)

Target: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNRF1 Antikörper ist konjugiert mit Cy5.5

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-ZNRF1 Antikörper (Cy5.5)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ZNRF1

Target: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Andere Bezeichnung: ZNRF1

Hintergrund:

Synonyms: E3 ubiquitin protein ligase ZNRF1, E3 ubiquitin-protein ligase ZNRF1, Nerve injury gene 283, Nerve injury induced gene 283 protein, Nerve injury-induced gene 283 protein, NIN283, Rnf42, Zinc and ring finger 1, zinc and ring finger protein 1, zinc finger and ring finger protein 1, Zinc/RING finger protein 1, ZNRF 1, znrf1, ZNRF1_HUMAN, Zrfp1.

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. ZNRF1 (zinc and ring finger 1), also known as NIN283, is a 227 amino acid protein that contains one RING-type zinc finger and localizes to the lysosome and the endosome, as well as to cytoplasmic vesicles and the peripheral membrane. Expressed primarily in nervous system tissue, but also present in testis and thymus, ZNRF1 functions as an E3 ubiquitin-protein ligase that is thought to play a role in the establishment and maintenance of neuronal plasticity. Multiple isoforms of ZNRF1 exist due to alternative splicing events.

Gen-ID: 84937