ELL3 Antikörper (AA 51-158) (Cy7)

Produktnummer ABIN1417598

Der Kaninchen Polyklonal Anti-ELL3-Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, ELL3 in Proben von Human zu detektieren.

Kurzübersicht für ELL3 Antikörper (AA 51-158) (Cy7) (ABIN1417598)

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELL3 Antikörper ist konjugiert mit Cy7

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-ELL3 Antikörper (Cy7)

Bindungsspezifität: AA 51-158

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ELL3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ELL3

Target: ELL3 (Elongation Factor RNA Polymerase II-Like 3 (ELL3))

Andere Bezeichnung: ELL3

Hintergrund:

Synonyms: B cell translocation gene 2, BTG family member 2, Btg2, BTG2_HUMAN, Nerve growth factor inducible anti prolerative, NGF inducible anti prolerative protein PC3, NGF-inducible anti-prolerative protein PC3, PC3, Pheochromacytoma cell 3, Protein BTG2, TIS21.

Background: Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.

Gen-ID: 80237

Pathways: Negative Regulation of intrinsic apoptotic Signaling