FBXW4 Antikörper (Cy5)

Produktnummer ABIN1416678

Der Cy5-konjugierte Kaninchen Polyklonal anti-FBXW4 Antikörper (ABIN1416678) detektiert spezifisch FBXW4 in IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für FBXW4 Antikörper (Cy5) (ABIN1416678)

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW4 Antikörper ist konjugiert mit Cy5

Applikation: Immunofluorescence (IF)

Produktdetails anti-FBXW4 Antikörper (Cy5)

Verwendungszweck: SHFM3 Polyclonal Antibody, Cy5 Conjugated

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SHFM3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IF=1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Andere Bezeichnung: SHFM3

Hintergrund:

Synonyms: DAC, Dactylin, F box and WD 40 domain containing protein 4, F box and WD 40 domain protein 4, F box and WD repeat domain containing 4, F box/WD repeat containing protein 4, F box/WD repeat protein 4, F-box and WD-40 domain-containing protein 4, F-box/WD repeat-containing protein 4, FBW 4, FBW4, FBWD 4, FBWD4, FBXW 4, FBXW4, FBXW4_HUMAN, SHFM 3, SHSF 3, SHSF3, Split hand/foot malformation ectrodactyly type.

Background: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.Involvement in disease:Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) . SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Gen-ID: 6468