Chromosome 5 Open Reading Frame 39 (C5orf39) (AA 50-100) Antikörper (Cy5)

Produktnummer ABIN1415045

Der Kaninchen Polyklonal Anti--Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, in Proben von Human zu detektieren.

Kurzübersicht für Chromosome 5 Open Reading Frame 39 (C5orf39) (AA 50-100) Antikörper (Cy5) (ABIN1415045)

Target: Chromosome 5 Open Reading Frame 39 (C5orf39)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: AA 50-100

Homologie: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Annexin-2 receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Chromosome 5 Open Reading Frame 39 (C5orf39)

Andere Bezeichnung: AX2R

Hintergrund:

Synonyms: LOC389289, ANXA2R, Annexin 2 receptor, Annexin II receptor, AX2R, AXIIR, C5orf39, Chromosome 5 open reading frame 39, AX2R_HUMAN.

Background: ANXA2R (annexin-2 receptor), also known as AX2R or C5orf39, is a 193 amino acid protein that is widely expressed and may act as an annexin II receptor on marrow stromal cells to induce osteoclast formation. In addition, ANXA2R is highly expressed in lymphocytes and is also found in resting CD4+ and CD8+ T cells. The gene encoding ANXA2R maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6 % of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.