Aspartate beta Hydroxylase Antikörper (AA 301-400) (HRP)

Produktnummer ABIN1413272

Der Kaninchen Polyklonal Anti-Aspartate beta Hydroxylase-Antikörper wurde für ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, Aspartate beta Hydroxylase in Proben von Human zu detektieren.

Kurzübersicht für Aspartate beta Hydroxylase Antikörper (AA 301-400) (HRP) (ABIN1413272)

Target: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aspartate beta Hydroxylase Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Aspartate beta Hydroxylase Antikörper (HRP)

Bindungsspezifität: AA 301-400

Homologie: Human,Mouse,Rat,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ASPH/Aspartate beta hydroxylase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Aspartate beta Hydroxylase

Target: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Andere Bezeichnung: ASPH/Aspartate beta hydroxylase

Hintergrund:

Synonyms: ASP beta hydroxylase, Aspartyl/asparaginyl beta hydroxylase, ASPH, BAH, CASQ2BP1, HAAH, JCTN, junctin, Peptide aspartate beta dioxygenase, ASPH_HUMAN.

Background: Aspartyl/asparaginyl beta-hydroxylase (ASPH) is a widely-expressed type II membrane protein involved in calcium homeostasis. Located in the endoplasmic reticulum, ASPH specifically hydroxylates an Asp or Asn residue in the epidermal growth factor-like (EGF) domains of several proteins, using iron as a cofactor. The ASPH gene encodes 3 proteins, ASPH, Junctin, and Junctate (or Humbug), that differ significantly in their C-terminal domains. These ASPH gene products are expressed as five transcript variants that differ by their roles in calcium storage and release, hydroxylation capabilities, and tissue specificity. While all ASPH variants are expressed in skeletal muscle, only some are detected in heart, brain, pancreas, placenta, lung, liver, and kidney tissues. In the lumen of the endoplasmic reticulum, ASPH can be processed into two different forms.

Pathways: Positive Regulation of Endopeptidase Activity