GDF6 Antikörper (AA 336-410) (Cy5.5)

Produktnummer ABIN1411547

Der Kaninchen Polyklonal Anti-GDF6-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, GDF6 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für GDF6 Antikörper (AA 336-410) (Cy5.5) (ABIN1411547)

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GDF6 Antikörper ist konjugiert mit Cy5.5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-GDF6 Antikörper (Cy5.5)

Bindungsspezifität: AA 336-410

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GDF6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Andere Bezeichnung: GDF6

Hintergrund:

Synonyms: bmp 13, bmp13, bmp-13, Cartilage Derived Morphogenetic Protein 2, cdmp 2, CDMP2, gdf 6, GDF16 , Growth dferentiation factor 6, Growth/dferentiation factor 6, GDF6_HUMAN.

Background: Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).