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UNC5B Antikörper (AA 188-260) (Cy5.5)

Der Kaninchen Polyklonal Anti-UNC5B-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, UNC5B in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN1409477

Kurzübersicht für UNC5B Antikörper (AA 188-260) (Cy5.5) (ABIN1409477)

Target

Alle UNC5B Antikörper anzeigen
UNC5B (Netrin receptor UNC5B (UNC5B))

Reaktivität

  • 36
  • 27
  • 21
  • 3
  • 3
Human, Maus, Ratte

Wirt

  • 33
  • 3
  • 2
Kaninchen

Klonalität

  • 36
  • 2
Polyklonal

Konjugat

  • 11
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser UNC5B Antikörper ist konjugiert mit Cy5.5

Applikation

  • 26
  • 14
  • 12
  • 12
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 188-260

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Dog,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human UNC5B

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    UNC5B (Netrin receptor UNC5B (UNC5B))

    Andere Bezeichnung

    UNC5B/UNC5H2

    Hintergrund

    Synonyms: Netrin receptor UNC5B, Netrin receptor UNC5B Precursor, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Protein XUNC 5, Transmembrane receptor Unc5H2, Unc 5 homolog 2, Unc 5 homolog B, UNC 5B, Unc5 C.elegans homolog b, Unc5b, UNC5B_HUMAN, UNC5H2.

    Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.

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