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EVC Antikörper (AA 251-350) (HRP)

This anti-EVC antibody (ABIN1408238) is a Rabbit Polyclonal antibody detecting EVC in ELISA, IHC (fro), IHC (p). Suitable for Human.
Produktnummer ABIN1408238

Kurzübersicht für EVC Antikörper (AA 251-350) (HRP) (ABIN1408238)

Target

Alle EVC Antikörper anzeigen
EVC (Ellis Van Creveld Syndrome (EVC))

Reaktivität

  • 25
  • 1
Human

Wirt

  • 21
  • 4
Kaninchen

Klonalität

  • 24
  • 1
Polyklonal

Konjugat

  • 8
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser EVC Antikörper ist konjugiert mit HRP

Applikation

  • 13
  • 13
  • 9
  • 7
  • 2
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 8
    • 2
    • 1
    AA 251-350

    Homologie

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human EVC1

    Isotyp

    IgG
  • Applikationshinweise

    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Handhabung

    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    EVC (Ellis Van Creveld Syndrome (EVC))

    Andere Bezeichnung

    EVC1

    Hintergrund

    Synonyms: Ellis van Creveld syndrome DWF 1, DWF1, Ellis van Creveld syndrome protein, Ellis-van Creveld syndrome, EVC, EVC1, EVC 1, EVC-1, EVCL, MGC105107, EVC_HUMAN.

    Background: EVC is an autosomal skeletal dysplasia caused by mutations in the EVC and EVC2 genes. Found in developing ribs, heart, kidney and lung, the EVC gene is responsible for normal development of the face, limbs, teeth and nails. The protein expressed by the EVC gene is an intracellular component of the hedgehog signal pathway that contains a leucine zipper and transmembrane domain. Defects in the EVC gene can lead to short-limb dwarfism, ectodermal dysplasia and cardiac anomalies such as irregular atrioventricular septum development. Additionally, the EVC gene has been implicated in Weyers acrodental dysostosis, an autosomal dominant disease characterized by facial abnormalities and limb defects.

    Pathways

    Hedgehog Signalweg
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