DERL1 Antikörper (AA 111-220) (Cy3)

Produktnummer ABIN1408149

Dieses Anti-DERL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DERL1 in IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für DERL1 Antikörper (AA 111-220) (Cy3) (ABIN1408149)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DERL1 Antikörper ist konjugiert mit Cy3

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-DERL1 Antikörper (Cy3)

Bindungsspezifität: AA 111-220

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DERLIN-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Andere Bezeichnung: DERLIN-1

Hintergrund:

Synonyms: Derlin1, Derlin1, Derlin 1, DER1, DER-1, DER 1, DERL1_HUMAN.

Background: Degradation in endoplasmic reticulum proteins, also designated Derlins or DERtrins, are crucial for the degradation of misfolded endoplasmic reticulum (ER) luminal proteins. Derlin proteins are multi-pass membrane proteins localizing to the ER. Derlins are involved in transferring misfolded proteins from the ER to the cytosol, where the misfolded proteins are destroyed in an ubiquitin-dependent manner by the proteasome. In the case of cytomegalovirus infection, Derlin-1, as opposed to Derlins-2 and -3, is involved in the export of MHC class I heavy chains from the ER via its interaction with the viral protein US11. Derlins may also be important for cell proliferation.

Gen-ID: 79139

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling