OLIG2 Antikörper (AA 81-180) (Cy5)

Produktnummer ABIN1407724

Produktdetails anti-OLIG2 Antikörper (Cy5)

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Bindungsspezifität: AA 81-180

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OLIG2 Antikörper ist konjugiert mit Cy5

Applikation: Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OLIG2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu OLIG2

Target: OLIG2 (Oligodendrocyte Lineage Transcription Factor 2 (OLIG2))

Andere Bezeichnung: OLIG2 (OLIG2 Produkte)

Synonyme: olig3.2 antikoerper, MGC89336 antikoerper, OLIG2 antikoerper, BHLHB1 antikoerper, OLIGO2 antikoerper, PRKCBP2 antikoerper, RACK17 antikoerper, bHLHe19 antikoerper, wu:fc64g09 antikoerper, AI604895 antikoerper, Bhlhb1 antikoerper, Olg-2 antikoerper, Oligo2 antikoerper, RK17 antikoerper, oligodendrocyte transcription factor 4 antikoerper, oligodendrocyte transcription factor 2 antikoerper, oligodendrocyte lineage transcription factor 2 antikoerper, olig4 antikoerper, OLIG2 antikoerper, Olig2 antikoerper, olig2 antikoerper

Hintergrund:

Synonyms: Basic domain helix loop helix protein class B 1, Basic helix loop helix protein class B 1, bHLHB1, bHLHe19, Class B basic helix loop helix protein 1, Class B basic helix-loop-helix protein 1, class E basic helix loop helix protein 19, Class E basic helix-loop-helix protein 19, Human protein kinase C binding protein RACK17, Olig2, OLIG2_HUMAN, Oligo2, Oligodendrocyte lineage transcription factor 2, Oligodendrocyte specic bHLH transcription factor 2, Oligodendrocyte transcription factor 2, PRKCBP2, Protein kinase C binding protein 2, Protein kinase C binding protein RACK17, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, RACK17.

Background: The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.