SH2D1A Antikörper (AbBy Fluor® 350)

Produktnummer ABIN1405161

Dieses Anti-SH2D1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SH2D1A in WB und IF (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für SH2D1A Antikörper (AbBy Fluor® 350) (ABIN1405161)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-SH2D1A Antikörper (AbBy Fluor® 350)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SH2D1A/SAP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A

Hintergrund:

Synonyms: SH2 domain protein 1A, DSHP, Duncan disease SH2 protein, SAP, Signaling lymphocyte activation molecule associated protein, SLAM associated protein, T cell signal transduction molecule SAP, SH21A_HUMAN.

Background: SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-?and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96 % homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).

Gen-ID: 4068

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process