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KCTD11 Antikörper (AbBy Fluor® 488)

KCTD11 Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 488
Produktnummer ABIN1403794
  • Target Alle KCTD11 Antikörper anzeigen
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    Reaktivität
    • 22
    • 18
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 21
    • 1
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KCTD11 Antikörper ist konjugiert mit AbBy Fluor® 488
    Applikation
    • 22
    • 12
    • 4
    • 2
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KCTD11
    Isotyp
    IgG
    Top Product
    Discover our top product KCTD11 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    KCTD11 (Potassium Channel Tetramerisation Domain Containing 11 (KCTD11))
    Andere Bezeichnung
    KCTD11 (KCTD11 Produkte)
    Synonyme
    KCTD11 antikoerper, AF465352 antikoerper, Ren antikoerper, C17orf36 antikoerper, KCASH1 antikoerper, REN antikoerper, REN/KCTD11 antikoerper, potassium channel tetramerization domain containing 11 antikoerper, potassium channel tetramerisation domain containing 11 antikoerper, KCTD11 antikoerper, Kctd11 antikoerper
    Hintergrund

    Synonyms: C17orf36, MGC 129844, Potassium channel tetramerisation domain containing 11, REN, Retinoic acid EGF NGF induced gene protein, C 17 orf 36, KCD11_HUMAN.

    Background: The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation, Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state.

    Gen-ID
    147040
    Pathways
    Hedgehog Signalweg
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