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Cullin 7 Antikörper (Biotin)

CUL7 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN1400989
  • Target Alle Cullin 7 (CUL7) Antikörper anzeigen
    Cullin 7 (CUL7)
    Reaktivität
    • 36
    • 23
    • 21
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 35
    • 1
    Kaninchen
    Klonalität
    • 35
    • 1
    Polyklonal
    Konjugat
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Cullin 7 Antikörper ist konjugiert mit Biotin
    Applikation
    • 28
    • 13
    • 8
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Cullin 7
    Isotyp
    IgG
    Top Product
    Discover our top product CUL7 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    Cullin 7 (CUL7)
    Andere Bezeichnung
    Cullin 7 (CUL7 Produkte)
    Synonyme
    cullin-7 antikoerper, CUL7 antikoerper, Cullin-7 antikoerper, KIAA0076 antikoerper, dJ20C7.5 antikoerper, 2510004L20Rik antikoerper, AA409809 antikoerper, C230011P08Rik antikoerper, p185 antikoerper, p193 antikoerper, cullin 7 antikoerper, CUL7 antikoerper, Cul7 antikoerper
    Hintergrund

    Synonyms: CUL-7, CUL7, CUL7_HUMAN, Cullin-7, dJ20C7.5, KIAA0076.

    Background: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity.Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies.

    Gen-ID
    9820
    Pathways
    ER-Nucleus Signaling
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