Transglutaminase 2 Antikörper (AA 351-450) (FITC)

Produktnummer ABIN1399904

Der Kaninchen Polyklonal Anti-Transglutaminase 2-Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, Transglutaminase 2 in Proben von Human und Maus zu detektieren.

Kurzübersicht für Transglutaminase 2 Antikörper (AA 351-450) (FITC) (ABIN1399904)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transglutaminase 2 Antikörper ist konjugiert mit FITC

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Transglutaminase 2 Antikörper (FITC)

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Transglutaminase 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Andere Bezeichnung: Transglutaminase 2

Hintergrund:

Synonyms: TG 2, TGC, TG2, TGase C, TGase H, TGase-2, TGase2, TgaseII, ALPHA SUBUNIT, C polypeptide, G alpha h, G protein alpha subunit Gh class, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, Guanine nucleotide binding protein H polypeptide, H POLYPEPTIDE, Protein glutamine gamma glutamyltransferase 2, Protein glutamine gamma glutamyltransferase, Protein-glutamine gamma-glutamyltransferase 2, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM 2, TGM2, TGM2_HUMAN, Tissue transglutaminase, Tissue type transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas.

Background: Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling