FBXW4 Antikörper (AA 171-270) (Biotin)

Produktnummer ABIN1398811

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FBXW4 in ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für FBXW4 Antikörper (AA 171-270) (Biotin) (ABIN1398811)

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FBXW4 Antikörper (Biotin)

Bindungsspezifität: AA 171-270

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SHFM3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu FBXW4

Target: FBXW4 (F-Box and WD Repeat Domain Containing 4 (FBXW4))

Andere Bezeichnung: SHFM3

Hintergrund:

Synonyms: DAC, Dactylin, F box and WD 40 domain containing protein 4, F box and WD 40 domain protein 4, F box and WD repeat domain containing 4, F box/WD repeat containing protein 4, F box/WD repeat protein 4, F-box and WD-40 domain-containing protein 4, F-box/WD repeat-containing protein 4, FBW 4, FBW4, FBWD 4, FBWD4, FBXW 4, FBXW4, FBXW4_HUMAN, SHFM 3, SHSF 3, SHSF3, Split hand/foot malformation ectrodactyly type.

Background: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.Involvement in disease:Defects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) . SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

Gen-ID: 6468