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KDM2A Antikörper (AA 741-840) (AbBy Fluor® 647)

Dieses Anti-KDM2A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KDM2A in IF (cc) und IF (p). Geeignet für Human.
Produktnummer ABIN1397613

Kurzübersicht für KDM2A Antikörper (AA 741-840) (AbBy Fluor® 647) (ABIN1397613)

Target

Alle KDM2A Antikörper anzeigen
KDM2A (Lysine (K)-Specific Demethylase 2A (KDM2A))

Reaktivität

  • 45
  • 18
  • 9
  • 8
  • 6
  • 6
  • 6
  • 6
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 42
  • 2
  • 1
Kaninchen

Klonalität

  • 44
  • 1
Polyklonal

Konjugat

  • 22
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser KDM2A Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation

  • 17
  • 15
  • 15
  • 8
  • 8
  • 7
  • 3
  • 3
  • 1
  • 1
  • 1
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 741-840

    Homologie

    Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human FBXL11

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    KDM2A (Lysine (K)-Specific Demethylase 2A (KDM2A))

    Andere Bezeichnung

    FBXL11

    Hintergrund

    Synonyms: [Histone-H3]-lysine-36 demethylase 1A, CXXC-type zinc finger protein 8, CXXC8, F box / LRR repeat protein 11, F box and leucine rich repeat protein 11, F box protein FBL7, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, FBL11, FBL7, FBXL11, JHDM1A, JmjC domain-containing histone demethylation protein 1A, kdm2a, KDM2A_HUMAN, Lysine-specic demethylase 2A.

    Background: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and protein recruitment. F-box proteins are members of a large family that regulate the cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, for degradation by the proteasome after ubiquitination. FBL11, also known as FBXL11 (F-box and leucine-rich repeat protein 11), CXXC8, KDM2A, JHDM1A (JmjC domain-containing histone demethylation protein 1A) or LILINA, is a 1,162 amino acid member of the F-box protein family that contains one F-box domain and localizes to the nucleus. Expressed ubiquitously with highest expression in testis, ovary and brain, FBL11 functions to demethylate the Lys-36 residue of histone H3, thereby modulating the histone code. Additionally, FBL11 is thought to promote the ubiquitination and subsequent degradation of various phosphorylated proteins. Three isoforms of FBL11 exist due to alternative splicing events.

    Gen-ID

    22992

    Pathways

    Warburg Effekt
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