Metabotropic Glutamate Receptor 1 Antikörper (AA 151-250) (Biotin)

Produktnummer ABIN1394641

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Metabotropic Glutamate Receptor 1 in ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Zebrafisch (Danio rerio).

Kurzübersicht für Metabotropic Glutamate Receptor 1 Antikörper (AA 151-250) (Biotin) (ABIN1394641)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reaktivität: Maus, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Metabotropic Glutamate Receptor 1 Antikörper (Biotin)

Bindungsspezifität: AA 151-250

Kreuzreaktivität: Maus, Zebrafisch (Danio rerio)

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MGLUR1A/Metabotropic Glutamate Receptor 1a

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Andere Bezeichnung: MGLUR1A/Metabotropic Glutamate Receptor 1a

Hintergrund:

Synonyms: G protein coupled receptor family C group 1 member A, Glutamate receptor metabotropic 1 alpha, Glutamate receptor metabotropic 1, GPRC1A, GRM 1, GRM1 alpha, GRM1, GRM1A, Human metabotropic glutamate receptor 1 alpha mRNA complete cds, Metabotropic glutamate receptor 1 alpha, Metabotropic glutamate receptor 1, mGlu1, MGLUR1, MGLUR1A, mGluR1alpha.

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.