CACNA1G/CACNA1H (AA 311-420) Antikörper (AbBy Fluor® 647)

Produktnummer ABIN1394478

This anti- antibody (ABIN1394478) is a Rabbit Polyclonal antibody detecting in IF (cc), IF (p). Suitable for Rat.

Kurzübersicht für CACNA1G/CACNA1H (AA 311-420) Antikörper (AbBy Fluor® 647) (ABIN1394478)

Target: CACNA1G/CACNA1H

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: AA 311-420

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from CACNA1G + CACNA1H

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: CACNA1G/CACNA1H

Andere Bezeichnung: CACNA1G + CACNA1H

Hintergrund:

Synonyms: Cav3.1c, Low voltage activated calcium channel alpha1 3.2 subunit, NBR13, Voltage dependent T type calcium channel subunit alpha 1G, Voltage dependent T type calcium channel subunit alpha 1H, Voltage gated calcium channel subunit alpha Cav3.1, Voltage gated calcium channel subunit alpha Cav3.2, CAC1G_HUMAN, CAC1H_HUMAN.

Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.