SH3PXD2A Antikörper (AA 261-360) (Biotin)

Produktnummer ABIN1392499

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SH3PXD2A in ELISA, IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für SH3PXD2A Antikörper (AA 261-360) (Biotin) (ABIN1392499)

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH3PXD2A Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SH3PXD2A Antikörper (Biotin)

Bindungsspezifität: AA 261-360

Kreuzreaktivität: Ratte

Homologie: Human,Mouse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FISH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SH3PXD2A

Target: SH3PXD2A (SH3 and PX Domains 2A (SH3PXD2A))

Andere Bezeichnung: FISH

Hintergrund:

Synonyms: Adapter protein TKS5, Five SH3 domain-containing protein, SH3 and PX domain-containing protein 2A, SH3 multiple domains protein 1, Sh3md1, Sh3pxd2a, SPD2A_HUMAN, TKs5, Tyrosine kinase substrate with five SH3 domains.

Background: Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo, catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).