GLIS2 Antikörper (AA 271-350) (Biotin)

Produktnummer ABIN1392031

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GLIS2 in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für GLIS2 Antikörper (AA 271-350) (Biotin) (ABIN1392031)

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLIS2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GLIS2 Antikörper (Biotin)

Bindungsspezifität: AA 271-350

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLIS2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu GLIS2

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Andere Bezeichnung: GLIS2

Hintergrund:

Synonyms: NPHP7, NKL, GLI kruppel family member 2, GLI similar 2, GLI-similar 2, GLIS 2, GLIS family zinc finger 2, glis2, GLIS2_HUMAN, Kruppel like zinc finger protein GLIS2, Neuronal Krueppel-like protein, Tax helper protein, THP, Zinc finger protein GLI2, Zinc finger protein GLIS2.

Background: GLIS2 is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family. By recruiting the corepressors CtBP1 and HDAC3, GLIS2 represses the transcriptional activation mediated by a??-catenin in the Wnt pathway. GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation. Mutations of GLIS2 may be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis. GLIS2 contains five tandem Cys(2)-His(2) zinc finger motifs that exhibit the highest homology to those of members of the GLI and Zic subfamilies of Kr??ppel-like proteins. GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta.