MCM4 Antikörper (AA 761-863) (AbBy Fluor® 350)

Produktnummer ABIN1390437

Dieses Anti-MCM4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MCM4 in WB, IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für MCM4 Antikörper (AA 761-863) (AbBy Fluor® 350) (ABIN1390437)

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM4 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-MCM4 Antikörper (AbBy Fluor® 350)

Bindungsspezifität: AA 761-863

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MCM4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MCM4

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Andere Bezeichnung: MCM4/CDC21

Hintergrund:

Synonyms: CDC21, CDC21 homolog, CDC54, DNA replication licensing factor MCM 4, DNA replication licensing factor MCM4, hCdc 21, hCdc21, Homolog of S. pombe cell devision cycle 21, KIAA4003, mcdc21, MCM 4, MCM 4 minichromosome maintenance deficient 4, MCM4, MCM4 minichromosome maintenance deficient 4, MCM4 minichromosome maintenance deficient 4, mitotin S. cerevisiae, MCM4_HUMAN, Mcmd4, MGC33310, Minichromosome Maintenance 4, Minichromosome maintenance complex component 4, Minichromosome maintenance deficient S. cerevisiae 4, Minichromosome maintenance deficient 4, Minichromosome maintenance deficient 4 homolog S. cerevisiae, Minichromosome maintenance, S. cerevisiae, homolog of, 4, mKIAA4003, P1 CDC21, P1-CDC21, P1CDC21, 19G antibody AI325074, AU045576, CDC 21, CDC 54.

Background: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis.

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA